Haloperidol plasma concentrations after equal oral dose administration are 40 to 50% higher in Chinese patients compared to Caucasian, Afro-American and Hispanic Americans. Likewise: to achieve similar haloperidol plasma levels the Chinese patients required lower doses (40-50% less) compared to Caucasians and Afro-American patients (Jann, 1992)

Pharmacokinetics China

Toxicity
Patients carrying HLA-B*1502 are at strongly increased risk for life treatening carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). See: special topics.
Liberation
 
Administration/absorption
 
Distribution
 
Metabolism

 

CYP1A2

There are no major interethnic differences in the expression of CYP1A2-related activity between Caucasians and Chinese, although Chinese women as a subgroup may exhibit comparatively lower enzyme activity (Bartoli, 1996).


CYP3A

 


CYP2B6

 


CYP2C8

 


CYP2C9

 


CYP2C19

 


CYP2D6

 
Excretion