There is a strong relationship between the HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome in the Thai population.
The odds ratio (relationship between the presence of HLA-B*1502 in at least 1 allele and carbamazepine-induced Stevens-Johnson syndrome) according to the meta-analysis of Tangamornsuksan et al (2013) is 54.43 (95%CI: 16.28-181.96).
HLA-B*1502 was present in 100% (4 of 4) of the patients with carbamazepine-induced Stevens-Johnson syndrome and 19% (8 of 42) of the carbamazepine-tolerant patients in this study. This revealed a 100% (95% CI: 61%–100%) sensitivity and 75% (95% CI: 67%–90%) specificity of HLA-B*1502 as a test for CBZ-SJS in the Thai population.
(N=31 Thai epileptic patients, King Chulalongkorn Memorial Hospital, Bangkok), (Locharernkul et al. 2008).